3. Patrick Mahomes Throws for 300 Yards, 3 TDs

The Chargers managed to contain the Bengals’ offense in Week 1 by limiting Cincinnati to just 13 points with 295 total yards of offense. Let’s not forget, that was Joe Burrow’s first ever NFL game after a strange offseason with no preseason.

It’s going to be much more difficult for the Chargers to attempt to slow down the Chiefs’ offense. Without Derwin James in the lineup due to a season-ending injury, it will be especially challenging for Los Angeles.

With the impact Clyde Edwards-Helaire provides in the ground-game, there isn’t as much of a need for Mahomes to put up insane passing numbers to win games. For reference, the 2018 NFL MVP only needed to record 211 passing yards and 3 touchdowns against the Texans in Week 1.

By the time the game is over, Mahomes will manage to exceed totals of 300 passing yards and 3 touchdown throws. The Chargers’ defense is tougher than what the Chiefs faced against the Texans and will need Mahomes to shoulder more of a load.