Year after year, football reminds us all of one important lesson. For as beautiful, as fun, as joyful and as exciting as it may be, it’s also cruel and unforgiving– and 2020 is the furthest thing from the exception.

For every otherworldly performance from Russell Wilson and surprise MVP-level showing from Josh Allen, for every game-within-the-game and potential breakout showing, there are just as many instances of crushing injuries that end up derailing seasons. In Week 2, NFL fans got the good with the bad, and in Week 3, those fans will feel the aftermath of both.

But between all of those highlights and lowlights leaves us all with plenty to watch for. From Super Bowl favorites adjusting to life after a cruel amount of injuries, to some dominant quarterbacks looking to continue their greatness, to everything in between– Week 3 of the NFL season should give us plenty of storylines to watch for. Here are the biggest five.