The New York Giants picked up a historic come-from-behind victory over the Arizona Cardinals in Week 2. After being shut out in the first half, making it 60-0 they had been outscored in the first six quarters of the season, the Giants turned things around in the second half.

New York scored on all five of their possessions, scoring the final 24 points of the game to steal a 31-28 victory away from the Cardinals. It was a season-saving victory as teams that go 0-2 to start the season rarely turn things around. A Thursday Night Football matchup against the San Francisco 49ers also looms.

But, it wasn’t all positive for the Giants, who witnessed star running back Saquon Barkley go down with an injury on the final drive of the game. When being tackled, a player fell on top of Barkley’s legs, leading to a lower-body injury.

It was bad enough that he had to be helped off the field by trainers as he couldn’t walk off under his own power. An original update painted a positive picture for him, as there were reports that he was walking okay after the game.

But, that update didn’t provide any insight into how severe the injury was or whether he would have to miss time. With such a quick turnaround for Week 3, there were serious doubts about his availability.

Barkley will be missing Thursday’s game and likely at least two more. The MRI that he underwent shows that Barkley suffered an ordinary ankle sprain according to ESPN’s Adam Schefter. He is expected to be sidelined for three weeks.

After this week’s matchup against San Francisco, the Giants are hosting the Seattle Seahawks on Monday Night Football in Week 4 before going back on the road to face the Miami Dolphins in Week 5. The matchup against Miami sounds like it is the soonest we will see Barkley back on the field.

That would mark exactly three weeks since the injury. If he is unable to go for that game, Week 6 on the road against the New England Patriots would almost certainly be his return date without any setbacks.