1. Giants Win by Comfortable Margin
A matchup featuring the 49ers and Giants is one that can’t be discussed without the mention of injuries to key players. It will have a substantial influence on the outcome of this game.
The 49ers still have talented contributors that will be ready to play in Week 3, but not having Jimmy Garoppolo could be too much to overcome. There won’t be enough firepower for San Francisco to hold a legitimate edge over the Giants on both ends.
The Giants face the possibility of becoming more one-dimensional without Saquon Barkley in the lineup — making things easier for an effective 49ers defense. Having Daniel Jones in the lineup will help New York to produce enough offensively to get the win.
The Giants will end up coming away with a win and it could be by a double-figure margin. Getting a win would mark New York’s first of the season and that will be important when considering their Week 4 opponent will be against the Rams.
